Nephrol Dial Transplant (2004) 19: 1625-1628
Nephrol Dial Transplant Vol. 19 No. 6 © ERA-EDTA 2004; all rights reserved
Case Report
Acute interstitial nephritis in a case of Ascaris lumbricoides infection
1Department of Nephrology, Johann Wolfgang Goethe-University, Frankfurt am Main and 2Department of Renal Pathology, Deutsches Krebsforschungszentrum, Heidelberg, Germany
Correspondence and offprint requests to: Dr I. A. Hauser, Klinikum der Johann Wolfgang Goethe-Universität, Medizinische Klinik IV, Funktionsbereich Nephrologie, D-60590 Frankfurt/Main, Germany. Email: i.hauser@em.uni-frankfurt.de
Keywords: acute interstitial nephritis; Ascaris lumbricoides; parasitosis
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| Introduction |
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Acute interstitial nephritis is an important cause of acute renal failure. The incidence of interstitial nephritis can only be estimated because of its minimal and non-specific symptoms except for the development of renal failure. Different studies focusing on apparently healthy individuals or unselected autopsy series estimate a prevalence of
1% [1,2]. It is assumed that acute interstitial nephritis is the cause of acute renal failure in
15% of cases [3]. Many causative factors leading to acute interstitial nephritis do exist, but may be categorized into distinctive groups: drug hypersensitivity reaction, infection, immune-mediated diseases, hereditary, metabolic and idiopathic forms. Within these broad categories, nowadays drugs are the predominant cause of interstitial nephritis, followed by infections and idiopathic lesions [4].
Acute pyelonephritis caused by renal invasion of virulent microorganisms has to be distinguished from acute interstitial nephritis, which can occasionally be seen in the
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