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NDT Advance Access originally published online on March 5, 2004
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Nephrol Dial Transplant (2004) 19: 1368-1373
Nephrol Dial Transplant Vol. 19 No. 6 © ERA-EDTA 2004; all rights reserved

Editorial Review

Voltage-dependent calcium channels in the renal microcirculation

Boye L. Jensen, Ulla G. Friis, Pernille B. Hansen, Ditte Andreasen, Torben Uhrenholt, Jeppe Schjerning and Ole Skøtt

Physiology and Pharmacology, University of Southern Denmark, Odense C, Denmark

Correspondence and offprint requests to: Boye L. Jensen, Physiology and Pharmacology, University of Southern Denmark, Winsløwparken 21, DK-5000 Odense C, Denmark. Email: bljensen@health.sdu.dk

Keywords: kidney; flour; current; arteriole

The first 150 words of the full text of this article appear below.

Introduction

Voltage-dependent calcium channels (Cav) play an important role in the excitation–contraction coupling in vascular smooth muscle by linking hormone-induced depolarization to calcium influx and contraction. In keeping with this central role of Cav, the channels are targets for pharmacological intervention in conditions such as hypertension.

Cav are heteromeric multisubunit proteins that are composed of an {alpha}1-subunit, and auxilliary ß- and {alpha}2{delta}-subunits. The Cav {alpha}1-subunit contains the essential components necessary and sufficient for the expression of voltage-gated calcium currents, i.e. the calcium pore, the voltage sensor and the drug-binding sites. Up to now, 10 genes encoding mRNAs for Cav {alpha}1-subunits have been cloned. Based on their electrophysiological characteristics, these gene products are divided into high voltage-activated (HVA) channels that need a large depolarization to be activated, and low voltage-activated (LVA) channels that are activated after rather limited depolarization. The HVA channels comprise L-type channels (Cav 1.1–1.4) and neuronal channels . . . [Full Text of this Article]

Cav mRNA in renal pre-glomerular microcirculation

L-type Cav [Cav 1.2 ({alpha}1C)] in the renal pre-glomerular microcirculation

P/Q-type Cav [Cav 2.1 ({alpha}1A)] in the renal pre-glomerular microcirculation

T-type Cav [Cav 3.1 ({alpha}1G) and Cav 3.2 ({alpha}1H)] in the renal pre-glomerular microcirculation

Heterogeneity of Cav in the renal microcirculation


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