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Nephrol Dial Transplant (2004) 19: 1302-1304
Nephrol Dial Transplant Vol. 19 No. 5 © ERA-EDTA 2004; all rights reserved

Case Report

Intracapillary proliferative glomerulonephritis due to heavy chain deposition disease

Anouk C. Vedder, Jan J. Weening and Raymond T. Krediet

Department of Medicine and Department of Pathology, Academic Medical Centre, University of Amsterdam, The Netherlands

Correspondence and offprint requests to: Dr R. T. Krediet, Academic Medical Centre, Renal Unit, PO Box 22700, 1100 DE Amsterdam, The Netherlands. Email: c.n.deboer@amc.uva.nl

Keywords: heavy chain deposition disease; intracapillary proliferative glomerulonephritis; plasmacell dyscrasia; renal biopsy; renal failure

The first 10% of the full text of this article appears below.



   Introduction
 
Heavy chain deposition disease (HCDD) is a rare manifestation of plasma cell dyscrasia. Only 11 cases have been described in the literature [1]. The clinical picture is variable, but in all patients renal biopsy showed a nodular sclerosing glomerulopathy [1–5]. We report a patient with rapidly progressive glomerulonephritis in whom the renal biopsy showed mainly intracapillary proliferative glomerulonephritis due to HCDD.



   Case
 
The patient is a 55-year-old musician with an uneventful medical history except ankylosing spondylitis diagnosed at the age of 47. Six weeks before admission he noticed foamy urine, at 2 weeks he developed generalized swelling, dyspnoea and a severe headache. Upon admission . . . [Full Text of this Article]



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