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Nephrol Dial Transplant (2004) 19: 733-735
Nephrol Dial Transplant Vol. 19 No. 3 (c) ERA-EDTA 2004; all rights reserved

Case Report

Thrombotic microangiopathy in a patient with Sezary syndrome treated with interferon-{alpha}

Marianna Politou1, Panagiotis Tsaftarides1, John Vassiliades1, Marina P. Siakantaris1, Spyros Michail2, Lydia Nakopoulou3, Gerassimos A. Pangalis1 and George Vaiopoulos1

1First Department of Internal Medicine and 3Department of Pathology, University of Athens Medical School and 2Department of Nephrology, Laikon General Hospital of Athens, Athens, Greece

Correspondence and offprint requests to: Marianna Politou, MD, First Department of Internal Medicine and University of Athens Medical School, Athens, Greece. Email: mpolitou@hotmail.com

Keywords: interferon-{alpha}; Sezary syndrome; thrombotic microangiopathy

The first 10% of the full text of this article appears below.



   Introduction
 
Sezary syndrome is a cutaneous T-cell lymphoma (CTCL), characterized by erythroderma and infiltration of the epidermis, the dermis and the bone marrow by monoclonal CD4+ T lymphocytes [1]. Renal complications of patients with CTCLs have rarely been reported [2–4]. In patients with other haematological malignancies, treated with interferon-{alpha}, renal complications have already been described [5]. We report here a rare case of Sezary syndrome, treated with interferon-{alpha}, who developed renal thrombotic microangiopathy (TMA).



   Case
 
A 63-year old male, who had been diagnosed with Sezary syndrome . . . [Full Text of this Article]



   Discussion
 

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