Nephrol Dial Transplant (2004) 19: 474-476
© 2004 European Renal Association–European Dialysis and Transplant Association
Case Report
IgG4-associated idiopathic tubulointerstitial nephritis complicating autoimmune pancreatitis
1Department of Internal Medicine and 2Department of Pathology, Kurobe City Hospital, Kurobe, Japan
Correspondence and offprint requests to: Shin-ichi Takeda, MD, Internal Medicine of Kurobe City Hospital, 1108-1 Mikkaichi, Kurobe 938-8502, Japan. Email: stakeda@med.kurobe.toyama.jp
Keywords: immunoglobulin G subclasses; pancreatitis; tubulointerstitial nephritis
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Introduction |
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It has been well documented that autoimmune pancreatitis (AIP) [1], also known as sclerosing pancreatitis [2], is frequently associated with fibrosclerotic diseases, such as Sjögren's syndrome [3,4], primary biliary cirrhosis [5], primary sclerosing cholangitis [3–5] or retroperitoneal fibrosis [6]. However, as yet, there have been no reports on renal complications of AIP, except for hydronephrosis, caused by retroperitoneal fibrosis. Recently, Hamano et al. [2] reported that the pathogenesis of sclerosing pancreatitis is closely related to the presence of immunoglobulin (Ig) G4. We describe here a patient with AIP in association with tubulointerstitial nephritis (TIN), which is strongly suspected to be induced by immune complexes containing IgG4.
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Case |
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In 1992, a 66-year-old male was admitted to the surgical department of our hospital because of obstructive jaundice. He gave no history of severe abdominal
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Discussion |
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