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Nephrol Dial Transplant (2004) 19: 469-473
© ERA–EDTA 2004; all rights reserved

Case Report

Nephrogenic fibrosing dermopathy: a novel, disabling disorder in patients with renal failure

Pieter Evenepoel1, Miranda Zeegers1, Siegfried Segaert2, Kathleen Claes1, Dirk Kuypers1, Bart Maes1, Patrick Flamen3, Sabine Fransis4 and Yves Vanrenterghem1

1Division of Nephrology, 2Division of Dermatology, 3Division of Nuclear Medicine and 4Division of Pathology, Department of Medicine, University Hospital Leuven, Leuven, Belgium

Correspondence and offprint requests to: P. Evenepoel, MD, PhD, Dienst Nefrologie, Universitair Ziekenhuis Gasthuisberg, Herestraat 49, B-3000 Leuven, Belgium. Email: pieter.evenepoel@uz.kuleuven.ac.be

Keywords: fibrosis; renal failure; skin disorder

The first 150 words of the full text of this article appear below.



   Introduction
 
Nephrogenic fibrosing dermopathy (NFD) is a rare, recently described cutaneous fibrosing disorder that primarily affects patients with a history of renal disease [1]. Since the first report in 2000 by Cowper et al., about 100 cases of NFD have been described worldwide, and clusters have been observed in dialysis units and medical centres in the US, the UK and Switzerland. The disorder is not limited to haemodialysis patients as was suggested by initial observations, but may also occur in patients receiving peritoneal dialysis and in patients suffering from renal insufficiency who never have been dialysed [1–4,7]. Patients typically develop acute, lumpy, plaque-like indurations involving the extremities, and occasionally the trunk and buttocks. The head is almost always spared. The diffuse skin thickening and hardening may be accompanied or preceded by isolated nodules and, rarely bullae. Pruritus and burning pain are common . . . [Full Text of this Article]



   Cases
 
Case 1
Case 2


   Discussion
 

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