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Nephrology Dialysis Transplantation 2004 19(12):3168-3171; doi:10.1093/ndt/gfh448
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Nephrol Dial Transplant Vol. 19 No. 12 © ERA-EDTA 2004; all rights reserved

Case Report

Cerebral vasculitis in a teenager with Goodpasture's syndrome

Nicola Gittins1, Anna Basu2, Janet Eyre2, Anil Gholkar3 and Nadeem Moghal2

1 Department of Paediatric Nephrology, 2 Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK and 3 Department of Neuroradiology, Newcastle General Hospital, NE4 6BE, UK

Correspondence and offprint requests to: Dr Anna Basu, BMBCh, Sir James Spence Institute, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK. Email: a.p.basu@ncl.ac.uk

Keywords: anti-glomerular basement membrane glomerulonephritis; central nervous system; child; vasculitis

The first 150 words of the full text of this article appear below.



   Introduction
 
Goodpasture's syndrome is a rare condition in childhood. We report a case in which a 14-year-old girl with Goodpasture's syndrome developed seizures due to central nervous system (CNS) vasculitis. At the time of the seizures, anti-neutrophil cytoplasmic antibodies (ANCA) were absent and her anti-glomerular basement membrane (anti-GBM) antibody titre had normalized following 3 weeks of plasma exchange and immunosuppressive therapy. This combination of events has not been reported previously in a child and raises questions as to the aetiology of the vasculitis.



   Case
 
A previously well 14-year-old girl presented with a 3 month history of increasing lethargy followed by a 2 week history of headache, abdominal pain, nausea and vomiting. There was no history of arthralgia, rash, cough or haemoptysis. On presentation, she was pale, but otherwise alert and well perfused. She had a systolic blood pressure of 180 mmHg. Her serum potassium was 7.6 mmol/l, urea 48 mmol/l and creatinine . . . [Full Text of this Article]



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