Skip Navigation


NDT Advance Access originally published online on October 26, 2004
Nephrology Dialysis Transplantation 2004 19(12):3098-3103; doi:10.1093/ndt/gfh540
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/12/3098    most recent
gfh540v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (16)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Lok, C. E.
Right arrow Articles by Hux, J. E.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lok, C. E.
Right arrow Articles by Hux, J. E.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant Vol. 19 No. 12 © ERA-EDTA 2004; all rights reserved

Original Article

The growing volume of diabetes-related dialysis: a population based study

Charmaine E. Lok1,2, Matthew J. Oliver3, Deanna M. Rothwell2 and Janet E. Hux2,3

1 Division of Nephrology, University Health Network, Toronto General Hospital, 2 Institute for Clinical Evaluative Sciences and 3 Department of Medicine, Sunnybrook & Women's College Health Sciences Centre, Toronto, Ontario, Canada

Correspondence and offprint requests to: Charmaine E. Lok, MD, Department of Medicine, Division of Nephrology, The Toronto General Hospital, 11 EN-216, 200 Elizabeth Street, Toronto, Ontario, M5G 2C4, Canada. Email: charmaine.lok{at}uhn.on.ca

Background. End-stage renal failure requiring dialysis is one of the most serious complications of diabetes mellitus, and diabetes is the most common cause of end-stage renal failure. The aim of this large, observational study is to describe the population-based incidence and prevalence rates and outcomes of diabetic individuals in Ontario, Canada who require dialysis therapy.

Methods. Two cohorts of patients, those with diabetes and those without, were created between April 1, 1994 and March 31, 2000 (total of ~8.4 million) and followed until March 31, 2001 using several large, linked administrative databases at the Institute for Clinical Evaluative Sciences. The incidence, prevalence and mortality on dialysis for each cohort were determined. A multivariate Cox proportional hazards analysis, adjusting for age, sex and co-morbidity, was used to determine the independent impact of diabetes on patient survival.

Results. The average annual incidence rate of dialysis was 12 times greater in persons with diabetes (130 per 100 000) vs without diabetes (11 per 100 000). By 1999–2000, diabetic patients comprised 51% of the incident dialysis population. The average annual prevalence rate was 10 times greater in the diabetic cohort. Patients with diabetes had more co-morbidities at the start of dialysis and poorer 3 year survival (55 vs 68%; P<0.0001).

Conclusions. The incident and prevalent rates of dialysis for patients with diabetes mellitus are many times the rates of those without diabetes. Patients with diabetes mellitus often start dialysis with significant co-morbidities, which may contribute to the relatively high rate of mortality on dialysis.

Keywords: diabetes; dialysis; population study; survival


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nephrol Dial TransplantHome page
R. Calderon-Margalit, E.-S. Gordon, M. Hoshen, J. D. Kark, A. Rotem, and Z. Haklai
Dialysis in Israel, 1989-2005--time trends and international comparisons
Nephrol. Dial. Transplant., February 1, 2008; 23(2): 659 - 664.
[Abstract] [Full Text] [PDF]

Home page
 QJMHome page
D. Nitsch, R. Burden, R. Steenkamp, D. Ansell, C. Byrne, F. Caskey, P. Roderick, and T. Feest
Patients with diabetic nephropathy on renal replacement therapy in England and Wales
QJM, September 1, 2007; 100(9): 551 - 560.
[Abstract] [Full Text] [PDF]

Home page
 Clin TrialsHome page
C. E. Lok, M. Allon, S. Donnelly, M. Dorval, B. Hemmelgarn, L. Moist, M. J. Oliver, M. Tonelli, and K. Stanley
Design of the fish oil inhibition of stenosis in hemodialysis grafts (FISH) study
Clinical Trials, August 1, 2007; 4(4): 357 - 367.
[Abstract] [PDF]

Home page
 Nephrol Dial TransplantHome page
N. Kamar, C. Mariat, M. Delahousse, J. Dantal, A. Al Najjar, E. Cassuto, N. Lefrancois, O. Cointault, G. Touchard, F. Villemain, et al.
Diabetes mellitus after kidney transplantation: a French multicentre observational study
Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1986 - 1993.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
M. S. Y. Thong, A. A. Kaptein, R. T. Krediet, E. W. Boeschoten, F. W. Dekker, and for the Netherlands Cooperative Study on the Adequ
Social support predicts survival in dialysis patients
Nephrol. Dial. Transplant., March 1, 2007; 22(3): 845 - 850.
[Abstract] [Full Text] [PDF]

Home page
 J. Am. Soc. Nephrol.Home page
C. E. Lok, M. Allon, L. Moist, M. J. Oliver, H. Shah, and D. Zimmerman
Risk Equation Determining Unsuccessful Cannulation Events and Failure to Maturation in Arteriovenous Fistulas (REDUCE FTM I)
J. Am. Soc. Nephrol., November 1, 2006; 17(11): 3204 - 3212.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
R. J. Hinchliffe, B. Kirk, D. Bhattacharjee, S. Roe, W. Jeffcoate, and F. Game
The effect of haemodialysis on transcutaneous oxygen tension in patients with diabetes--a pilot study
Nephrol. Dial. Transplant., July 1, 2006; 21(7): 1981 - 1983.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.