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Nephrology Dialysis Transplantation 2004 19(11):2896-2900; doi:10.1093/ndt/gfh412
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Nephrol Dial Transplant Vol. 19 No. 11 © ERA-EDTA 2004; all rights reserved

Case Report

An immunosuppressed patient with systemic vasculitis suffering from cerebral abscesses due to Nocardia farcinica identified by 16S rRNA gene universal PCR

Andreas Sonesson1, Björn Öqvist2, Per Hagstam3, Isabella M. Björkman-Burtscher4, Håkan Miörner1 and Ann Cathrine Petersson1

1 Department of Clinical Microbiology and Immunology, 2 Department of Nephrology, 3 Department of Infectious Diseases and 4 Department of Diagnostic Radiology, Lund University Hospital, Lund, Sweden

Correspondence and offprint requests to: Ann Cathrine Petersson, PhD, Department of Clinical Microbiology and Immunology, Lund University Hospital, S221 85 Lund, Sweden. Email: Ann-Cathrine.Petersson@skane.se

Keywords: amikacin; cerebral abscess; immunosuppression; Nocardia farcinica; PCR; 16S rDNA

The first 150 words of the full text of this article appear below.



   Introduction
 
Nocardia spp. are Gram-positive, partially or variably acid-fast filamentous, branching rods of aerobic actinomycetes [1]. The most common primary site for infection in man is the respiratory tract [1,2]. Brain abscess is the most common clinical manifestation of central nervous system (CNS) infection [1]. The majority of the patients affected have underlying chronic diseases or suffer from endogenous or drug-induced immunosuppression [2,3], but the pathogen can also infect persons without any risk factors [2]. However, the course of the infection tends to be more severe and prolonged in immunocompromised hosts than in patients with normal cell-mediated immunity [4]. The symptoms of brain abscesses are often non-specific and include the classic triad of fever, headache and focal neurological deficiency [2,3]. It is important to establish the appropriate microbial diagnosis, as the . . . [Full Text of this Article]



   Case
 
16S gene universal PCR
Post-mortem culture


   Discussion
 

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