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NDT Advance Access originally published online on September 7, 2004
Nephrology Dialysis Transplantation 2004 19(11):2846-2851; doi:10.1093/ndt/gfh483
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Nephrol Dial Transplant Vol. 19 No. 11 © ERA-EDTA 2004; all rights reserved

Original Article

No association between renin–angiotensin system gene polymorphisms and early and long-term allograft dysfunction in kidney transplant recipients

Torsten Slowinski1, Petra Diehr1, Patrick Kleemann1, Lutz Fritsche1, Lutz Renders3, Klemens Budde1, Ingeborg A Hauser2, Hans H. Neumayer1 and Berthold Hocher4,5

1 Center for Cardiovascular Research/Klinik für Nephrologie, Charité, Humboldt Universität Berlin, Germany, 2 Medizinische Klinik IV, Friedrich-Alexander-Universität Erlangen-Nürnberg, Germany, 3 Klinik für Nephrologie, Universitätsklinikum Kiel, Germany, 4 Center for Cardiovascular Research/Institute of Pharmacology, Charité, Humboldt Universität Berlin, Germany and 5 Division of Nephrology and Hypertension, Inselspital, Berne, Switzerland

Correspondence and offprint requests to: Priv. Doz. Dr Berthold Hocher, Division of Nephrology and Hypertension, Inselspital, Freiburgstr. 15, CH-3010 Berne, Switzerland. Email: berthold.hocher{at}insel.ch

Background. Genes determining the activity of the renin–angiotensin system (RAS) may be alloantigen-independent factors influencing kidney allograft function. We determined if gene polymorphisms of the RAS are associated with early and long-term post-transplantation graft dysfunction in 405 Caucasian kidney recipients with graft survivals of >2 years.

Methods. We calculated the slopes of serum creatinine–1/year and urinary protein excretion/year to follow graft function over time. Subjects were genotyped for the deletion (D) polymorphism of the gene encoding angiotensin I-converting enzyme, the angiotensin II-receptor type1 gene 1166A-C polymorphism and the M235T polymorphism of the angiotensinogen gene.

Results. The frequencies of factors predicting graft function were similar in patients with different genotypes. None of the polymorphisms influenced need for dialysis in the first week after transplantation, occurrence of at least one rejection episode, the slope of serum creatinine–1/year or the slope of urinary protein excretion/year. Results were independent of blood pressure or the use of angiotensin-converting enzyme inhibitors and angiotensin-receptor blockers or calcineurin inhibitors. The combination of genotypes did not influence the indicators of early and long-term graft dysfunction.

Conclusions. Neither the investigated gene polymorphisms of the RAS in kidney allograft recipients nor their combinations have an impact on early and long-term graft dysfunction.

Keywords: angiotensin I-converting enzyme; angiotensin II-receptor type 1; angiotensinogen; chronic graft dysfunction; gene polymorphism; kidney transplantation


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