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Nephrology Dialysis Transplantation 2004 19(10):2653-2656; doi:10.1093/ndt/gfh375
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Nephrol Dial Transplant Vol. 19 No. 10 © ERA-EDTA 2004; all rights reserved

Case Report

Development of transplant renal artery thrombosis and signs of haemolytic-uraemic syndrome following the change from cyclosporin to tacrolimus in a renal transplant patient

Ahmet Alper Kiykim1, Caner Ozer2, Altan Yildiz2, Naci Tiftik3, Mehmet Senli1, Ebru Kelebek1, Erdal Doruk4 and Erdem Akbay4

1 Division of Nephrology, Department of Internal Medicine, 2 Department of Radiology, 3 Division of Hematology, Department of Internal Medicine and 4 Department of Urology, Faculty of Medicine, University of Mersin, Turkey

Correspondence and offprint requests to: Yrd. Doç. Dr Ahmet Alper Kiykim, Nefroloji Bilim Dali Baskani, Mersin Üniversitesi Tip Fakültesi, 33079 Mersin, Turkey. Email: aakiykim@yahoo.com or ahmetkiykim@mersin.edu.tr

Keywords: haemolytic-uraemic syndrome; tacrolimus; transplant renal artery thrombosis

The first 150 words of the full text of this article appear below.



   Introduction
 
The clinical presentation of post-transplantation thrombotic microangiopathy (TMA) is variable. Often, TMA will manifest systemically as haemolytic-uraemic syndrome (HUS), with classic findings of renal failure, haemolytic anaemia, schistocytes and thrombocytopenia [1]. Localized and systemic TMA represent a spectrum of severity of the same disorder, not two different disorders with distinct pathophysiological states. Pre-transplantation HUS, anticardiolipin antibodies, acute rejection, cytomegalovirus (CMV) and some medications are associated with the development of TMA. Herein we report a patient who developed the signs and symptoms of de novo HUS and transplant renal artery thrombosis following switching from cyclosporin to tacrolimus.



   Case
 
The patient is a 38-year-old Turkish woman whose primary cause of renal failure was bilateral nephrolithiasis. She had a gradual development of end-stage renal disease (ESRD) without a previous renal history of thrombotic microangiopathy. She had been on haemodialysis for 10 months. The renal transplantation had been performed from a 2-antigen mismatched, . . . [Full Text of this Article]



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 Nephrol Dial TransplantHome page
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