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Nephrology Dialysis Transplantation 2004 19(10):2650-2652; doi:10.1093/ndt/gfh434
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Nephrol Dial Transplant Vol. 19 No. 10 © ERA-EDTA 2004; all rights reserved


Case Report

Recurrence of IgM nephropathy in a renal allograft

Andrew H. J. Salmon, Dia Kamel and Peter W. Mathieson

Academic Renal Unit, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK

Correspondence and offprint requests to: Peter W. Mathieson, Academic Renal Unit, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB, UK. Email: p.mathieson@bris.ac.uk

Keywords: allograft; IgM nephropathy; recurrence; renal

The first 150 words of the full text of this article appear below.



   Introduction
 
IgM nephropathy has been defined as ‘primary diffuse mesangioproliferative glomerulonephritis with IgM being deposited diffusely in the mesangium as the sole or dominant immunoglobulin on immunofluorescence examination’ [1]. IgM nephropathy was first described in 1978, in a series of 12 cases whose initial native renal biopsy specimens displayed mild glomerular mesangial hypercellularity on light microscopy, diffuse granular mesangial IgM deposition on immunofluorescence examination, and in whom systemic disease and other glomerulonephritides were excluded [2]. A series of 54 patients with IgM nephropathy used the same definition [1]. In both these series [1,2], a spectrum of clinical findings was noted, but the majority had heavy proteinuria with a normal creatinine at the time of original biopsy, and a poor response to prednisolone and immunomodulatory agents. Progression to end-stage renal failure was noted in a minority [1], only in patients . . . [Full Text of this Article]



   Case
 


   Discussion
 

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