Skip Navigation


NDT Advance Access originally published online on July 27, 2004
Nephrology Dialysis Transplantation 2004 19(10):2480-2486; doi:10.1093/ndt/gfh413
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow All Versions of this Article:
19/10/2480    most recent
gfh413v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (3)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Joo, K. W.
Right arrow Articles by Han, J. S.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Joo, K. W.
Right arrow Articles by Han, J. S.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant Vol. 19 No. 10 © ERA-EDTA 2004; all rights reserved

Original Article

Antidiuretic action of oxytocin is associated with increased urinary excretion of aquaporin-2

Kwon Wook Joo1, Un Sil Jeon2, Gheun-Ho Kim3, Jungwhan Park1, Yoon Kyu Oh4, Yon Su Kim1, Curie Ahn1, Suhnggwon Kim1, Seong Yeon Kim1, Jung Sang Lee1 and Jin Suk Han1

1 Department of Internal Medicine, Seoul National University, Clinical Research Institute of Seoul National University Hospital, 2 Department of Internal Medicine, Korea Cancer Center Hospital, 3 Department of Internal Medicine, Hanyang University and 4 Department of Internal Medicine, Eulji Medical College, Seoul, Korea

Correspondence and offprint requests to: Jin Suk Han MD, PhD, Department of Internal Medicine, Seoul National University, Clinical Research Institute of Seoul National University Hospital, 28, Yongun-dong, Chongno-gu, Seoul 110-744, South Korea. Email: jshan{at}snu.ac.kr

Background. The antidiuretic effect of oxytocin in humans is controversial. Urinary excretion of aquaporin-2 (AQP2) can be used as an index of the action of vasopressin on the kidney. We investigated whether exogenous oxytocin affects urinary concentration and urinary AQP2 excretion in human beings.

Methods. Oxytocin was administered intravenously at a rate of 20 mU/min in 10 healthy volunteers, seven patients with central diabetes insipidus (CDI) and three patients with nephrogenic diabetes insipidus (NDI). On the next day, 2 µg of 1-desamino-8-D-arginine vasopressin (dDAVP) was injected subcutaneously. Two-hour urine was collected before and after the administration of oxytocin and dDAVP, and urinary AQP2 was measured semi-quantitatively by western analysis.

Results. Urine volume and free water clearance were decreased, and urine osmolality was increased by the administration of oxytocin or dDAVP in the normal volunteers and CDI patients. Urinary AQP2 excretion was increased by oxytocin infusion in the normal volunteers (from 34±12 to 326±120 densitometry unit (DU)/2 h) and in the CDI group (from 8±2 to 227±92 DU/2 h) (P<0.05), but not in the NDI group. dDAVP also had a similar but more potent effect on the urinary excretion of AQP2 in the normal and CDI groups.

Conclusions. Oxytocin has an antidiuretic effect and increases the urinary excretion of AQP2 in humans whose urinary concentration mechanism is preserved. These results suggest that AQP2 might have a regulatory role in the antidiuretic action of oxytocin in humans.

Keywords: antidiuretic; human; oxytocin; urinary AQP2


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Am. J. Physiol. Renal Physiol.Home page
R. Bouley, N. Pastor-Soler, O. Cohen, M. McLaughlin, S. Breton, and D. Brown
Stimulation of AQP2 membrane insertion in renal epithelial cells in vitro and in vivo by the cGMP phosphodiesterase inhibitor sildenafil citrate (Viagra)
Am J Physiol Renal Physiol, June 1, 2005; 288(6): F1103 - F1112.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.