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Nephrol Dial Transplant (2004) 19: 39-42
© ERA–EDTA 2003; all rights reserved

Child-Adult Interface

Diagnostic and therapeutic strategies in hyperoxaluria: a plea for early intervention

Bernd Hoppe1 and Ernst Leumann2

1University Children's Hospital, Division of Paediatric Nephrology, University of Cologne, Germany and 2University Children's Hospital, Division of Paediatric Nephrology, Zurich, Switzerland

Correspondence and offprint requests to: Bernd Hoppe, MD, University Children's Hospital, Division of Paediatric Nephrology, Josef-Stelzmann Strasse 9, D-50931 Cologne, Germany. Email: bernd.hoppe@medizin.uni-koeln.de

Keywords: diagnosis; primary hyperoxaluria; secondary hyperoxaluria; transplantation; treatment

The first 150 words of the full text of this article appear below.



   Introduction
 
Oxalic acid is an end product of human metabolism and does not appear to be needed for any process in the body. Under normal conditions the daily load of oxalate deriving from endogenous production and intestinal absorption is fully excreted by the kidneys. Up to a certain extent renal oxalate excretion may even keep pace with an elevated oxalate load, yet at the expense of hyperoxaluria, a major risk factor for recurrent nephrolithiasis and nephrocalcinosis [1,2]. Unfortunately, hyperoxaluria is all too often overlooked at this stage. The situation becomes far more serious if renal function is impaired (e.g. from complications of hyperoxaluria): the amount of oxalate excreted in the urine will no longer match its production and absorption, resulting in progressive oxalate retention with renal and extrarenal deposition of calcium oxalate, i.e. systemic oxalosis [3]. In a recent survey from the US ~30% of . . . [Full Text of this Article]



   Diagnosis
 


   Conservative treatment
 
Measures to lower the oxalate load
Measures to increase the urinary solubility of calcium oxalate


   Dialysis
 
Transplantation in primary hyperoxaluria


   Outlook
 

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M. Daudon, P. Jungers, and D. Bazin
Peculiar Morphology of Stones in Primary Hyperoxaluria
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C. F. M. Franssen
Oxalate clearance by haemodialysis--a comparison of seven dialysers
Nephrol. Dial. Transplant., September 1, 2005; 20(9): 1916 - 1921.
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