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Nephrol Dial Transplant (2004) 19: 252-254
© European Renal Association–European Dialysis and Transplant Association

Teaching Point
(Section Editor: K. Kühn)

Supported by an educational grant from

Creutzfeldt–Jakob-like EEG in a patient with end-stage renal failure

Chiao-Lin Chuang1, Kun-Po Chen2, Shang-Yeong Kwan3 and Wu-Chang Yang1

1Division of Nephrology, Department of Medicine, 3Section of Epilepsy, Neurological Institute, Taipei Veterans General Hospital and National Yang-Ming University School of Medicine and 2Taipei City Psychiatric Center, Taiwan

Correspondence and offprint requests to: Chiao-Lin Chuang, MD, Division of Nephrology, Department of Medicine, Taipei Veterans General Hospital, No. 201, Sec 2, Shih-Pai Road, Taipei 112, Taiwan. Email: clchuang@vghtpe.gov.tw

Keywords: ceftazidime; Creutzfeldt–Jakob disease; electroencephalogram; haemodialysis

The first 10% of the full text of this article appears below.



   Introduction
 
Ceftazidime is a widely used third-generation cephalosporin with structural similarities to penicillins, and has been reported to cause encephalopathy in the setting of inappropriate dosage. We present here a case of ceftazidime intoxication with neurological manifestations and electroencephalogram (EEG) patterns similar to that seen in the Creutzfeldt–Jakob disease (CJD). All of the patient's symptoms subsided and the EEG normalized after drug cessation and daily haemodialysis, suggesting an adverse response to ceftazidime.



   Case report
 
A 76-year-old woman, on maintenance haemodialysis for 3 years as a consequence of chronic glomerulonephritis, came to our hospital with an infection of her arteriovenous fistula. On admission, she was afebrile, mentally fully oriented and had a blood pressure of 140/80 mmHg. Her physical examination was remarkable for erythema and purulence on the . . . [Full Text of this Article]



   Discussion
 


   Teaching points
 

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