Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (8)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Shiizaki, K.
Right arrow Articles by Akizawa, T.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Shiizaki, K.
Right arrow Articles by Akizawa, T.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2003) 18: III42-III46
© 2003 European Renal Association-European Dialysis and Transplant Association

Original Article

Effect of percutaneous calcitriol injection therapy on secondary hyperparathyroidism in uraemic patients

Kazuhiro Shiizaki1,, Shigeo Negi1, Masahide Mizobuchi1, Ikuji Hatamura2, Nobuhiko Narukawa1, Toshifumi Sakaguchi1, Yukiko Kitabata1, Shinji Sumikado1 and Tadao Akizawa1

1 Center of Blood Purification Therapy and 2 The First Department of Pathology, Wakayama Medical University, Wakayama, Japan

Background. The impetus to develop percutaneous calcitriol injection therapy (PCIT) was the lack of therapeutic tools to treat secondary hyperparathyroidism (2HPT) resistant to medical therapy.

Methods. Nine dialysis patients resistant to intravenous calcitriol or calcitriol analogues underwent daily PCIT 5–10 times consecutively. The PCIT involved the injection of a volume of calcitriol equal to that of the enlarged parathyroid glands (PTGs) under ultrasonographic guidance. All patients had follow-up intravenous calcitriol after PCIT.

Results. The serum intact PTH concentration was markedly reduced following PCIT and was maintained for 12 weeks with intravenous calcitriol without significant changes in serum adjusted calcium and phosphorus concentrations. All patients tolerated PCIT without serious adverse events. Serum bone alkaline phosphatase concentrations and the volume of the enlarged PTGs were also significantly reduced.

Conclusion. PCIT is a safe and effective treatment, which may also suppress parathyroid hyperplasia and improve bone turnover for refractory 2HPT.

Keywords: calcitriol; end-stage renal disease (ESRD); interventional ultrasonography; renal osteodystrophy; secondary hyperparathyroidism

Correspondence and offprint requests to: Kazuhiro Shiizaki, Center of Blood Purification Therapy, Wakayama Medical University, 811-1 Kimiidera Wakayama 641-0012, Japan. Email: shiizaki{at}wakayama-med.ac.jp


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 NDT PlusHome page
K. Shiizaki, I. Hatamura, S. Negi, E. Nakazawa, R. Tozawa, S. Izawa, T. Akizawa, and E. Kusano
Cellular changes following direct vitamin D injection into the uraemia-induced hyperplastic parathyroid gland
NDT Plus, August 1, 2008; 1(suppl_3): iii42 - iii48.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
K. Shiizaki, I. Hatamura, S. Negi, T. Sakaguchi, F. Saji, I. Imazeki, E. Kusano, T. Shigematsu, and T. Akizawa
Highly Concentrated Calcitriol and its Analogues Induce Apoptosis of Parathyroid Cells and Regression of the Hyperplastic Gland Study in Rats
Nephrol. Dial. Transplant., December 21, 2007; (2007) gfm850v1.
[Abstract] [Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
T. Drueke, D. Martin, and M. Rodriguez
Can calcimimetics inhibit parathyroid hyperplasia? Evidence from preclinical studies
Nephrol. Dial. Transplant., July 1, 2007; 22(7): 1828 - 1839.
[Full Text] [PDF]

Home page
 Nephrol Dial TransplantHome page
K. Shiizaki, N. Hayakawa, I. Imazeki, I. Hatamura, T. Okada, S. Negi, T. Sakaguchi, T. Shigematsu, and T. Akizawa
Binding of highly concentrated maxacalcitol to the nuclear vitamin D receptors of parathyroid cells
Nephrol. Dial. Transplant., April 1, 2007; 22(4): 1078 - 1086.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.