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Nephrol Dial Transplant (2003) 18: III18-III22
© 2003 European Renal Association-European Dialysis and Transplant Association

Original Article

Adenovirus-mediated functional gene transfer into parathyroid cells in vivo and in vitro

Yoshiko Iwasaki1,, Takatoshi Kakuta2, Hiroaki Haruguchi3, Naoko Fukuda4, Kiyoshi Kurokawa2 and Masafumi Fukagawa5

1 Division of Nephrology and Clinical Research Center, Tokyo Teishin Hospital, Tokyo, 2 Division of Nephrology, Tokai University School of Medicine, Bouseidai, Isehara-city, 3 Third Department of Surgery, Tokyo Women's Medical College Hospital, Tokyo, 4 Division of Nephrology, Tokyo University School of Medicine, Tokyo and 5 Division of Nephrology and Dialysis Center, Kobe University School of Medicine, Japan

Chronic renal failure patients usually develop secondary hyperparathyroidism and, as the disease progresses, there is a decrease in the number of vitamin D and calcium-sensing receptors (CaRs) in the parathyroid glands. Parathyroid cell function can be controlled if a functional gene is transferred into these cells using an adenovirus vector. Vitamin D or CaR genes transferred by the infected adenovirus vector induced a reduction in parathyroid hormone secretion. These results suggest that adenovirus-mediated gene transfer is a useful technique for control of parathyroid cell function.

Keywords: adenovirus; calcium-sensing receptor; functional gene transfer; vitamin D receptor

Correspondence and offprint requests to: Yoshiko Iwasaki, Department of Health Sciences, Oita University of Nursing and Health Sciences, 2944-9, Megusuno, Notsuharu, Oita, 870-120, Japan. Email: ishizuka{at}oita-nhs.ac.jp, iwasakiy-tky{at}umin.ac.jp


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