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Nephrol Dial Transplant (2003) 18: 1660-1662
© 2003 European Renal Association-European Dialysis and Transplant Association

Case Report

Amoxicillin-induced acute renal failure

Georg Fritz1, Christoph Barner1, Ralf Schindler2, Willehad Boemke1 and Konrad Falke1

1 Department of Anesthesiology and Operative Intensive Care Medicine and 2 Medical Clinic, Department of Nephrology and Internal Intensive Care Medicine, University Hospital Charité, Campus Virchow Clinic, Berlin, Germany

Correspondence and offprint requests to: Georg Fritz, Department of Anesthesiology and Operative Intensive Care Medicine, University Hospital Charité, Campus Virchow, Augustenburger Platz 1, D-13353 Berlin, Germany. Email: georg.fritz@charite.de

Keywords: acute renal failure; amoxicillin; antibiotics; epilepsy; surgery

The first 10% of the full text of this article appears below.



   Introduction
 
Because of its favourable pharmacokinetics and antimicrobial efficacy, amoxicillin is widely used for perioperative antibiotic prophylaxis. We report here three cases of acute renal failure following the administration of amoxicillin during epilepsy surgery.



   Case 1
 
A 50-year-old Caucasian woman suffering from temporal lobe epilepsy refractory to antiepileptic drugs (AED) from the age of 2 years was admitted for partial left temporal lobe resection after extensive evaluation and non-invasive monitoring for determination of her epileptogenic focus. She was in good health without previous or concomitant diseases. Her medication consisted of carbamazepine 600 mg b.d. Laboratory work including creatinine (0.7 mg/dl) and urea (28 mg/dl) revealed no pathological findings. For perioperative antibiotic cover she received 4.4 g amoxicillin/clavulanic acid intravenously. Because there was no urine output even after 2 h after the start of surgery, an ultrasound of the abdomen was performed which showed an empty bladder with a Fowley-catheter . . . [Full Text of this Article]



   Case 2
 


   Case 3
 


   Discussion
 

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