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Nephrol Dial Transplant (2003) 18: 1260-1265
© 2003 European Renal Association-European Dialysis and Transplant Association

Invited Comment

Recurrent glomerulonephritis following renal transplantation: an update

Jürgen Floege

Division of Nephrology and Immunology, University of Aachen, Germany

Keywords: focal segmental glomerulosclerosis; graft loss; Henoch–Schönlein purpura; IgA nephropathy; membranous glomerulonephritis; membranoproliferative glomerulonephritis

The first 150 words of the full text of this article appear below.

Introduction

Based on the literature, recurrent disease is observed in 4–20% of the patients receiving a kidney transplant and will lead to graft failure in 2–5% [1–6]. In a large study of the University of Wisconsin/USA that evaluated 1557 patients, followed for a mean of 7.3 years after transplantation, recurrence of the underlying disease was observed in 98 cases, i.e. 8% [7]. More than 75% of these cases were recurrent glomerulonephritides (GN) and the present discussion will therefore be limited to these disease entities. However, before going into detail, it should be realized that the above data need to be treated with great caution for a number of reasons.

  • Patient groups in many studies are small and variable.
  • Studies have frequently followed patients for relatively short times after transplantation.
  • In particular in countries with a restrictive renal biopsy policy, up to 50% of the underlying . . . [Full Text of this Article]

Impact of recurrent glomerulonephritis on graft survival

Focal segmental glomerulosclerosis (FSGS)
Membranous glomerulonephritis
Mesangioproliferative (mesangiocapillary) glomerulonephritis (MPGN)
IgA nephropathy (IgAN)
Anti-GBM nephritis
Recommendations on how to follow patients with underlying glomerulonephritis after renal transplantation


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