Nephrol Dial Transplant (2003) 18: 931-936
© 2003 European Renal Association-European Dialysis and Transplant Association
Blood 8-hydroxy-2'-deoxyguanosine is associated with erythropoietin resistance in haemodialysis patients
1 Division of Nephrology, Endocrinology and Metabolism, Shizuoka Cancer Center Hospital, Shizuoka, 2 Department of Clinical Nutrition, School of Food and Nutritional Science, University of Shizuoka, Shizuoka and 3 First Department of Medicine, Hamamatsu University School of Medicine, Hamamatsu, Japan
Background. 8-Hydroxy-2'-deoxyguanosine (8-OHdG), a product of oxidized DNA, is increased in haemodialysis (HD) patients, but the clinical relevance of enhanced 8-OHdG production in these patients remains unknown.
Methods. We cross-sectionally measured serum 8-OHdG in 73 patients on maintenance HD (age 68±2 years, time on HD 85±11 months, male/female=42/31), and examined the relationship between blood 8-OHdG and the severity of renal anaemia and the weekly dosage of recombinant human erythropoietin (rHuEPO).
Results. There was a significant increase in serum 8-OHdG in HD patients compared with normal subjects. Serum 8-OHdG was positively correlated with the patients' age (r=0.231, P<0.05) but not with the duration of HD. Serum 8-OHdG was significantly higher in diabetic subjects than in non-diabetic subjects (P<0.05). Serum 8-OHdG had a significant inverse correlation with haemoglobin (Hb) (r=-0.526, P<0.01) but a positive correlation with the rHuEPO dose (r=0.443, P<0.01) and the ratio of the weekly rHuEPO dose divided by Hb (r=0.487, P<0.01). Serum 8-OHdG was not correlated with inflammatory and nutritional parameters.
Conclusions. These findings suggest that the elevation of circulating 8-OHdG may be associated, at least in part, with rHuEPO resistance in HD patients.
Keywords: anaemia; erythropoietin; haemodialysis; MDA; 8-OhdG
Correspondence and offprint requests to: Akihiko Kato, MD, Division of Nephrology, Endocrine and Metabolism, Shizuoka Cancer Center Hospital, 1007 Shimonagakubo, Nagaizumi-cho, Sunto-gun, Shizuoka 411-8777, Japan. Email: a.kato{at}scchr.jp
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