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Nephrol Dial Transplant (2003) 18: 1009-1012
© 2003 European Renal Association-European Dialysis and Transplant Association

Case Report

Hyperacute onset of haemolytic–uraemic syndrome associated with hyperacute rejection in the recipient of an ABO-incompatible kidney

Hiroshi Harada1,, Masaki Togashi2, Toshimori Seki2, Junri Shindo1, Naohiko Shimoda1, Yayoi Ogawa3, Akio Takada3, Masatoshi Tateno3, Hidetoshi Sato3 and Tetsuo Hirano1

Departments of 1 Renal Transplantation, 2 Urology and 3 Pathology, Sapporo City General Hospital, Sapporo, Japan

Keywords: ABO-incompatible; complication; haemolytic–uraemic syndrome; hyperacute rejection; renal transplantation

The first 150 words of the full text of this article appear below.



   Introduction
 
Haemolytic–uraemic syndrome (HUS), characterized by microangiopathic haemolysis, thrombocytopenia and renal dysfunction, is uncommon but can result in serious complications in transplantations of kidneys, and even other organs [1]. Any factors that damage vascular endothelial cells can trigger HUS [2,3]. Humoral vascular rejection and calcineurin inhibitors such as cyclosporin A (CSA) and tacrolimus are recognized as factors that instigate HUS in organ transplantation [4,5]. Meanwhile, an extreme shortage of organ donors necessitates widening the sources of donated organs, e.g. to ABO-incompatible donors [6]; well-refined pre- and post-operative treatments, including powerful immunosuppresion and diminution of anti-A and -B antibodies using plasmapheresis, make this possible [7,8]. The major cause of early graft loss is hyperacute and acute humoral rejection brought on by abundant antibodies against surface A or B antigens ubiquitously expressed on cell surfaces [6. . . [Full Text of this Article]



   Case
 


   Discussion
 

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