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Nephrol Dial Transplant (2003) 18: 426-428
© 2003 European Renal Association-European Dialysis and Transplant Association

Case Report

Invasive urothelial carcinoma after exposure to Chinese herbal medicine containing aristolochic acid may occur without severe renal failure

Joëlle L. Nortier1, Heinz H. Schmeiser4, Marie-Carmen Muniz Martinez1, Volker M. Arlt5, Catherine Vervaet2, Christian H. Garbar3, Philippe Daelemans2 and Jean-Louis Vanherweghem1,

1 Department of Nephrology, 2 Department of Stomatology and 3 Department of Pathology, Erasme Hospital, Université Libre de Bruxelles, Brussels, Belgium, 4 Division of Molecular Toxicology, German Cancer Research Center, Heidelberg, Germany and 5 Institute of Cancer Research, Haddow Laboratories, Sutton, UK

Keywords: Aristolochia fangchi; aristolochic acid; carcinogenicity; Chinese-herb nephropathy; DNA adducts; herbal remedies

The first 10% of the full text of this article appears below.



   Introduction
 
Chinese-herb nephropathy (CHN) was initially reported as a progressive renal interstitial fibrosis caused by the regular intake of Chinese herbal medicine belonging to the Aristolochia species containing nephrotoxic and carcinogenic aristolochic acid (AA) [1–3]. Prior exposure to AA was attested by the detection of specific DNA adducts formed by AA metabolites in kidneys and ureters of patients suffering from end-stage renal disease (ESRD) due to CHN [4–6]. Among these patients, a high prevalence of upper urinary tract carcinoma was observed [5,7]. . . . [Full Text of this Article]



   Case
 


   Discussion
 

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