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Nephrol Dial Transplant (2003) 18: 252-257
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comment

New insights in dialysis membrane biocompatibility: relevance of adsorption properties and heparin binding

Jacques Chanard, Sylvie Lavaud, Christine Randoux and Philippe Rieu

Service de Néphrologie, Centre Hospitalier et Universitaire et CNRS FRE 2260, Reims, France

Keywords: biocompatibility; dialysis membranes; extracorporeal devices; haemodialysis

The first 150 words of the full text of this article appear below.

Introduction

In the last 10 years, the concept of biocompatibility as applied to haemodialysis membranes has gained a general clinical acceptance in light of the knowledge that the clinical expression of ß2-microglobulin (ß2m) amyloidosis found in long-term haemodialyzed patients was governed by the characteristics of dialysis membranes. Highly permeable and biocompatible synthetic membranes interfere with the clinical expression of the disease and postpone occurrence of carpal tunnel syndrome and juxta-articular bone cysts [1–4]. Biocompatibility is a difficult concept to define in the absence of well-established clinical correlates. Besides ‘anaphylactoid reactions' [5], which are related more frequently to contaminated dialysate or leachable chemicals than to the sustained activation of the contact phase of coagulation in patients treated with angiotensin converting enzyme inhibitors [6,7], the concept of biocompatibility refers to any harmful effects induced by the contact of blood with dialysis . . . [Full Text of this Article]

Membrane components and effect of extracorporeal devices

Physicochemical mechanisms associated with membrane biocompatibility

Haemocompatibility of dialysis membranes

Dialysis membrane adsorption

Heparin coating of dialysis membrane

Membrane biocompatibility, nutrition and atherosclerosis

Conclusion: adsorption as a specific characteristic of biocompatible dialysis membranes


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[Abstract] [Full Text] [PDF]