Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF) Freely available
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (5)
Right arrowRequest Permissions
Right arrow Disclaimer
Google Scholar
Right arrow Articles by Jarraya, F.
Right arrow Articles by Hachicha, J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jarraya, F.
Right arrow Articles by Hachicha, J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nephrol Dial Transplant (2003) 18: 2421-2423

Case Report

Myeloperoxidase-antineutrophil cytoplasmic antibody-positive crescentic glomerulonephritis associated with benzylthiouracil therapy: report of the first case

Faiçal Jarraya1, Mohamed Abid2, Rachid Jlidi3, Khaled Mkaouar1, Mouna Mnif2, Mahmoud Kharrat1, Khaled Charfeddine1, Khaoula Kammoun1, Mohamed Ben Hmida1 and Jamil Hachicha1

1Department of Nephrology, 2Department of Endocrinology and 3Department of Pathology, Hedi Chaker University Hospital, Sfax, Tunisia

Correspondence and offprint requests to: Dr Faiçal Jarraya, Nephrology Department, Hedi Chaker University Hospital, Sfax 3029, Tunisia. Email: faijar@excite.com

Keywords: acute renal failure; ANCA; benzylthiouracil; crescentic glomerulonephritis; Grave’s disease

The first 10% of the full text of this article appears below.



   Introduction
 
Grave’s disease is a common form of autoimmune thyroiditis which has been successfully treated with anti-thyroid drugs for more than half a century. However, these drugs may cause major complications including agranulocytosis, hepatotoxicity and immunological disturbances such as lupus erythematosus syndrome.

Anti myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) mediated crescentic glomerulonephritis in association with anti-thyroid treatment was first described in 1994 [1]. In the literature, 22 cases have been reported to date. All were associated with propylthiouracil (PTU), except two [2–5]. One of the latter was associated with thiamazole (TMZ) [6] and the other with carbimazole (CMZ) therapy [7].

We report here the first case of an anti MPO-ANCA-positive crescentic glomerulonephritis . . . [Full Text of this Article]



   Case
 


   Discussion
 

Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?