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Nephrol Dial Transplant (2003) 18: 2209-2210
© 2003 European Renal Association-European Dialysis and Transplant Association

Editorial Comment

Pieces of the preeclampsia puzzle

Friedrich C. Luft

Franz Volhard Clinic, HELIOS Klinikum-Berlin, Medical Faculty of the Charité, Humboldt University, Berlin, Germany

Correspondence and offprint requests to: Friedrich C. Luft, MD, Franz Volhard Clinic, HELIOS Klinikum-Berlin, Medical Faculty of the Charité, Humboldt University, Wiltberg Strasse 50, D-13125 Berlin, Germany. Email: luft@fvk-berlin.de

Keywords: ADMA; angiotensin; preeclampsia; VEGF

The first 10% of the full text of this article appears below.

Introduction

Several interesting articles have been published recently that address novel mechanisms for preeclampsia. These mechanisms all involve circulating factors, a favourite topic for preeclampsia researchers. These factors may interfere with angiogenesis, engage angiotensin (Ang) II signalling, and directly impair endothelial function.

VEGF, PlGF and sFlt1

Vascular endothelial growth factor (VEGF) must be very busy during pregnancy. The growth factor’s receptor, fms-like tyrosine kinase 1 (Flt1), exists in two forms, namely a membrane-bound receptor tyrosine kinase that transmits angiogenic signals and a soluble secreted ectodomain (sFlt1), which may capture VEGF and keep the growth factor from its active bound receptor. Maynard et al. [. . . [Full Text of this Article]

Agonistic antibodies against AT1 receptors

ADMA

Possible interactions of apparently divergent pathways?

More questions than answers


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C. A. Hubel, G. Wallukat, M. Wolf, F. Herse, A. Rajakumar, J. M. Roberts, N. Markovic, R. Thadhani, F. C. Luft, and R. Dechend
Agonistic Angiotensin II Type 1 Receptor Autoantibodies in Postpartum Women With a History of Preeclampsia
Hypertension, March 1, 2007; 49(3): 612 - 617.
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