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Nephrol Dial Transplant (2002) 17: 1689-1691
© 2002 European Renal Association-European Dialysis and Transplant Association

Case Reports

Efficacy of haemodiafiltration treatment with PEPA dialysis membranes in plasma free light chain removal in a patient with primary amyloidosis

Toshihiko Machiguchi*,, Tadao Tamura and Haruyoshi Yoshida*

Department of Internal Medicine, Himeji National Hospital, Himeji, Japan

Keywords: dimethyl sulfoxide; free light-chain; haemodiafiltration; high performance membrane; polyester-polymer alloy membrane; primary amyloidosis

The first 10% of the full text of this article appears below.



   Introduction
 
Primary amyloidosis is a disease that causes intractable nephrotic syndrome, with continuous progression to end-stage renal failure (ESRF) [1,2]. Furthermore, it causes fatal cardiac conditions such as conduction disturbance and restrictive heart failure [3]. Although regular haemodialysis (HD) therapy has been attempted for ESRF in primary amyloidosis, a successful therapy has not been established yet [1,3]. In this study of a patient with primary amyloidosis, we estimated the removal ratio of free light (L)-chain—a precursor of amyloid fibril—by various blood purification methods. In addition, we examined the usefulness of dimethyl sulfoxide (DMSO).



   Case
 
A 58-year-old woman was admitted to Himeji National Hospital because of systemic oedema. Moderate proteinuria had been noted 6 months earlier. On admission, her blood pressure (BP) was 132/84 mmHg, controlled with a Ca2+-antagonist, manidipine (10 mg/day), and her pulse was regular at 76/min. Urinalysis . . . [Full Text of this Article]



   Discussion
 

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