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Nephrol Dial Transplant (2002) 17: 1546-1547
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

A KQ121 variant in the PC-1 gene and diabetic nephropathy: discrepant results between North and South Europe

Michel Marre

Service d'Endocrinologie Diabétologie Métabolisme Nutrition, Centre Hospitalier Universitaire BICHAT – Claude BERNARD, Paris, France

Keywords: diabetic nephropathy; glomerular filtration rate; KQ121 polymorphism; PC-1 gene

The first 10% of the full text of this article appears below.

In the August 2002 issue of this journal, two groups reported discrepant results on the effects of a polymorphism in a candidate gene for nephropathy in type 1 diabetes, i.e. PC-1 [1,2]. A K121Q polymorphism can affect PC1, a membrane glycoprotein known to inhibit insulin signalling. Insulin resistance can affect the risk of nephropathy in type 1 diabetes [3. . . [Full Text of this Article]


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