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Nephrol Dial Transplant (2002) 17: 1119-1121
© 2002 European Renal Association-European Dialysis and Transplant Association

Case Reports

Prednisone-induced neutropenia after cadaveric kidney transplantation

Stefan Schaub,1, Michael Dickenmann1, Ewa Cynke1, Andreas Bircher2 and Jürg Steiger1

1 Division of Transplantation Immunology and Nephrology and 2 Division of Allergology, University Hospital Basel, Basel, Switzerland

Keywords: cadaveric kidney transplantation; deflazacort; leukopenia; methylprednisolone; neutropenia; prednisone



   Introduction
 
Leukopenia is a common problem after kidney transplantation, with a wide differential diagnosis. Usually it is induced by drugs (e.g. azathioprine, mycophenolate mofetil, ganciclovir, co-trimoxazole) or infections (e.g. cytomegalovirus). Rare causes are post-transplantation lymphoproliferative disease (PTLD) and recurrence of pre-existing autoimmune disorders like systemic lupus erythematosus (SLE) or Wegener's granulomatosis.



   Case
 
A 44-year-old man was diagnosed with a biopsy-proven p-ANCA-positive rapidly progressive glomerulonephritis in August 1996. His initial creatinine was 474 µmol/l. He was treated with 1 g methylprednisolone intravenously for 3 days, followed by 75 mg prednisone (1 mg/kg bodyweight) and 150 mg cyclophosphamide per day for 1 month without improvement of the renal function. Therapy was thereafter discontinued and dialysis treatment initiated in September 1996. During the steroid/cyclophosphamide therapy and dialysis from September 1996 to August 1999, no leukopenia was observed. On 7 August 1999, the patient underwent cadaveric kidney transplantation. . . . [Full Text of this Article]



   Discussion
 


   Notes
 


   References
 

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