Nephrol Dial Transplant (2002) 17: 560-562
© 2002 European Renal Association-European Dialysis and Transplant Association
Child - Adult Interface
Cortical scintigraphy and urinary tract infection in children
Centre Hospitalo-Universitaire St Pierre, Department of Radioisotopes, Brussels, Belgium
Keywords: children; cortical scintigraphy; urinary tract infection
Introduction
Detection of renal cortical lesions by means of radioisotopes is one of the most widely used techniques in the field of paediatric nuclear medicine. Various substances have been proposed for that purpose, but there is presently a wide consensus on the preferential use of dimercaptosuccinic acid (DMSA) labelled with Technetium-99m. This tracer was introduced in 1974, but it is only since the late 1980s that numerous publications have appeared, related to the methodology, the robustness of the technique and the field of clinical applications.
Methodological aspects of Tc-99m DMSA scintigraphy
About 48% of the injected activity is excreted after 1 h and 2630% after 14 h, while 4050% of the activity accumulates in the kidney after 67 h. The tracer is taken up by the proximal tubular cells, directly from the peritubular vessels, and is therefore located in the outer layer of the kidney with minimal activity in the medulla and the calyces. As a consequence,
Sensitivity and specificity
Interpretation of images obtained
Place in management of urinary tract infection
Notes
References