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Nephrol Dial Transplant (2002) 17: 560-562
© 2002 European Renal Association-European Dialysis and Transplant Association


Child - Adult Interface

Cortical scintigraphy and urinary tract infection in children

Amy Piepsz

Centre Hospitalo-Universitaire St Pierre, Department of Radioisotopes, Brussels, Belgium

Keywords: children; cortical scintigraphy; urinary tract infection

Introduction

Detection of renal cortical lesions by means of radioisotopes is one of the most widely used techniques in the field of paediatric nuclear medicine. Various substances have been proposed for that purpose, but there is presently a wide consensus on the preferential use of dimercaptosuccinic acid (DMSA) labelled with Technetium-99m. This tracer was introduced in 1974, but it is only since the late 1980s that numerous publications have appeared, related to the methodology, the robustness of the technique and the field of clinical applications.

Methodological aspects of Tc-99m DMSA scintigraphy

About 4–8% of the injected activity is excreted after 1 h and 26–30% after 14 h, while 40–50% of the activity accumulates in the kidney after 6–7 h. The tracer is taken up by the proximal tubular cells, directly from the peritubular vessels, and is therefore located in the outer layer of the kidney with minimal activity in the medulla and the calyces. As a consequence, . . . [Full Text of this Article]

Sensitivity and specificity

Interpretation of images obtained

Place in management of urinary tract infection

Notes

References


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