Nephrol Dial Transplant (2002) 17: 526-528
© 2002 European Renal Association-European Dialysis and Transplant Association
Letters
Renal function, proteinuria and ACE-inhibitor therapy as determinants of plasma levels of endothelial markers
My
liwiec
Department of Nephrology and Internal Medicine Medical Academy Bia
ystok, Poland
Sir,
Dysfunction of vascular endothelial cells (ECs) is of growing importance in chronic renal failure (CRF) patients in view of its deleterious link with haemostatic abnormalities [1] and accelerated atherosclerosis [2]. Elevated blood levels of some EC-derived substances are established markers of endothelial activation and/or injury in various disorders [2], including CRF itself [3]. However, plasma levels of these molecules could vary depending on reduced glomerular filtration rate and increased permeability of the glomeruli. Associations between circulating EC markers and progression of renal failure and proteinuria have been the main interest of our study.
We measured the plasma concentrations of soluble thrombomodulin (sTM), antigens (Ag) of tissue factor (TF) and of the main TF inhibitor (tissue factor pathway inhibitor, TFPI), as well as
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References