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Nephrol Dial Transplant (2002) 17: 524-525
© 2002 European Renal Association-European Dialysis and Transplant Association

Letters

Aristolochic acid as a causative factor in a case of Chinese herbal nephropathy

Antonia J. Cronin1, Geoffrey Maidment1, Terry Cook2, Geoffrey C. Kite3, Monique S. J. Simmonds3, Charles D. Pusey2 and Graham M. Lord2,

1 Department of Medicine Wexham Park Hospital Slough 2 Department of Renal Medicine and Transplantation Hammersmith Hospital London 3 Royal Botanic Gardens Kew Richmond Surrey, UK

Sir,

Chinese herbal nephropathy (CHN) is a newly described type of interstitial nephritis with a characteristic histological pattern. It was initially described in a series of Belgian patients who were inadvertently given a contaminated herbal preparation as part of a slimming regimen [1]. The toxic agent was putatively identified as ‘aristolochic acid’ (AA), the active principle from species of Aristolochia now known to be a mixture of nitrophenanthrene derivatives such as aristolochic . . . [Full Text of this Article]

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 MutagenesisHome page
V. M. Arlt, M. Stiborova, and H. H. Schmeiser
Aristolochic acid as a probable human cancer hazard in herbal remedies: a review
Mutagenesis, July 1, 2002; 17(4): 265 - 277.
[Abstract] [Full Text] [PDF]