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Nephrol Dial Transplant (2002) 17: 195-198
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

‘The road not taken’: role of angiotensin II type 2 receptor in pathophysiology

Gunter Wolf

Department of Medicine, Division of Nephrology and Osteology, University of Hamburg, Hamburg, Germany

‘Two roads diverged in a wood, and I,

I took the one less traveled by,

And that has made all the difference’

From ‘The Road Not Taken’ by Robert Frost (1874–1963).

Introduction

Robert Frost's famous poem from 1915 is usually interpreted as a declaration of individualism reflected in taking the ‘less traveled’ road. However, it has been also argued in a more unphilosophical way that this poem is just a mocking satire on a hesitant hiking friend of Frost's who always speculated what would have happened if he had chosen their path differently.

The two roads of angiotensin II (ANG II) action are AT1 and AT2 receptors [1]. There may be even more types of ANG II receptors, but they are not yet cloned, resembling more small tracks than major highways of ANG II signalling. AT1 receptors are responsible for mediating many of the well-known stimulatory physiological . . . [Full Text of this Article]

AT2 receptors and inflammation

AT2 receptors, growth stimulation, and fibrosis

Do the diverging roads make a difference?

Notes

References


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