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Nephrol Dial Transplant (2002) 17: 2081-2083
© 2002 European Renal Association-European Dialysis and Transplant Association

Controversy

Taking anti-neutrophil cytoplasmic antibody (ANCA) testing beyond the limits

Fokko J. van der Woude

Vth Medical University Clinic (Nephrology, Endocrinology, Rheumatology), Faculty for Clinical Medicine at Mannheim, Karl-Ruprechts-Universität Heidelberg, Klinikum Mannheim, Mannheim, Germany

Keywords: ANCA

The first 10% of the full text of this article appears below.

The application of anti-neutrophil cytoplasmic antibody (ANCA) testing has received much interest since ANCA were discovered [1] and since they were reported to be useful in both the diagnosis and monitoring of disease activity in Wegener's granulomatosis (WG) [2]. Although there is little doubt that the recognition of the association between the presence of ANCA and active vasculitis has had a very positive influence on research on the pathogenesis and treatment of ANCA-associated diseases (reviewed by Savage [3]), there are reasons to worry about the application of this recently gained knowledge in clinical practice. In this comment the problems with the clinical application of ANCA tests are categorized for the sake of clarity as (i) standardization problems, (ii) difficulties with application of the test in the appropriate . . . [Full Text of this Article]

Standardization

The diagnostic value of ANCA testing depends on the clinical setting

ANCA and disease activity

Conclusions


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