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Nephrol Dial Transplant (2002) 17: 2020-2022
© 2002 European Renal Association-European Dialysis and Transplant Association

Case Reports

Renal failure following cardiac transplantation—think of the arteries

Robert Dedi, Graham Woodrow, Aleck M. Brownjohn and John H. Turney

Department of Renal Medicine, Leeds General Infirmary, Leeds, UK

Keywords: cardiac transplantation; renal artery stenosis

The first 150 words of the full text of this article appear below.



   Introduction
 
Following the improved survival of cardiac transplant recipients, attention has been drawn to the long-term complications, including renal dysfunction, resulting in substantial effects on morbidity and mortality [1]. A large body of evidence suggests that the primary cause of renal dysfunction is cyclosporin A (CsA) therapy. However, renal failure is not universal, and seems to bear little relationship to CsA dose or trough levels [1,2], suggesting the presence of other contributing factors.

Atherosclerotic renovascular disease is an increasingly common cause of renal failure in the general population, and is associated with those features that also predict dysfunction after cardiac transplantation. In addition, the histopathological changes found in association with renal-artery stenosis are similar to those presumed to be secondary to CsA toxicity. However, the studies of renal failure following cardiac allografting have not looked for renal-artery disease in sufficient detail to exclude this as . . . [Full Text of this Article]



   Cases
 
Case 1
Case 2
Case 3
Case 4


   Discussion
 

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