Nephrol Dial Transplant (2002) 17: 1867-1871
© 2002 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Megalin and cubilin—the story of two multipurpose receptors unfolds
1 Institut National de la Santé et de la Recherche Médicale U538, Centre Hospitalier Universitaire, St Antoine, 75012 Paris, France and 2 Department of Cell Biology, Institute of Anatomy, University of Aarhus, DK-8000 Aarhus C, Denmark
Keywords: CUB domains; Imerslund–Gräsbeck syndrome; kidney; LDL-receptor family; megaloblastic anaemia; vitamin D
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Introduction
Under physiological conditions, the renal tubular clearance of protein appears to be very efficient. However, the molecular mechanisms responsible for the endocytic uptake of protein in the renal proximal tubule have until recently been largely unknown. Within the last few years, two endocytic receptors, megalin and cubilin, have been shown to be extremely important for this process. The two multi-ligand receptors are strongly expressed in the apical part of epithelial cells in the renal proximal tubule (Figure 1
). At the subcellular level they are co-localized in apical clathrin coated pits and endosomes, i.e. in the early endocytic compartments (Figure 2). In addition, they are also detected in the dense apical tubules that provide for the recycling of apical membrane and receptors. Expression in the late endocytic compartments and lysosomes appears more limited. It is interesting to note that both megalin and cubilin are massively expressed in the yolk
Molecular structure
Megalin
Cubilin
Expression
Functions
Conclusion
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