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Nephrol Dial Transplant (2002) 17: 1731-1736
© 2002 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

New lessons from old assays: parathyroid hormone (PTH), its receptors, and the potential biological relevance of PTH fragments

William G. Goodman1,, Isidro B. Salusky2 and Harald Jüppner3

1 Division of Nephrology, Department of Medicine and 2 Division of Pediatric Nephrology, Department of Pediatrics, UCLA School of Medicine, Los Angeles, California and 3 Endocrine Unit, Massachusetts General Hospital, Boston, Massachusetts, USA

Keywords: C-terminal; N-terminal; parathyroid hormone; parathyroid hormone receptors; radioimmunoassay

The first 150 words of the full text of this article appear below.

Introduction

Accurate and reliable measurements of the concentration of parathyroid hormone (PTH) in serum or plasma are necessary for the diagnostic assessment of various clinical disorders of bone and mineral metabolism [1,2]. In patients with chronic renal failure, serum or plasma PTH levels are commonly used to identify different subtypes of renal osteodystrophy and to monitor evolution of the disorder [3–10]. Largely for practical reasons, plasma PTH levels serve as surrogates for bone histology in patients with end-stage renal disease (ESRD), and they are an essential guide to ongoing clinical management, particularly during the treatment of secondary hyperparathyroidism with vitamin D sterols [11–13].

It is now generally recognized that the several PTH assays that have been employed widely for many years do not measure exclusively the full-length biologically active hormone comprised of 84 amino acids, or PTH(1–84) [14. . . [Full Text of this Article]

Secretion and metabolism of PTH

Assays for PTH

PTH-derived peptides and other PTH receptors

PTH and the regulation of bone metabolism in renal failure


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