Nephrol Dial Transplant (2002) 17: 1728-1730
© 2002 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
Circulating endothelial cells: life, death, detachment and repair of the endothelial cell layer
Division of Nephrology, Department of Medicine, Hannover Medical School, Hannover, Germany
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Introduction
Circulating endothelial cells (CECs) were first detected in the 1970s although convenient techniques to isolate them have only recently become available [1]. These cells have now been shown to be present in a variety of vascular disorders but only a few reports have appeared since the mid-1990s. Very recently we were able to demonstrate grossly elevated numbers of CECs as a novel marker of disease activity in patients with ANCA-associated vasculitis [2]. It appears that this approach to vascular injury has not been appreciated so far and that its use should be evaluated in other vascular disorders as well.
Circulating endothelial cells
Early on, CECs were detected
Life, death and detachment of the endothelial cell layer
Mechanisms of endothelial repair: progenitor cells for rescue
Perspectives
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