Nephrol Dial Transplant (2002) 17: 172-174
© 2002 European Renal Association-European Dialysis and Transplant Association
Letters
Focal glomerulosclerosis expanding from the glomerular vascular pole in a Japanese male with mitochondrial-DNA mutation
1 Internal Medicine 2 Pathology of Kurobe City Hospital, Kurobe, Toyama 3 First Department of Internal Medicine and Division of Blood Purification, Kanazawa University School of Medicine Kanazawa, Ishikawa, Japan
Sir,
Recently mitochondrial DNA mutations have been detected in patients with various diseases, in particular, mitochondrial encephalomyopathies. With regard to renal involvement, renal tubular dysfunction resulting in renal tubular acidosis and de-Toni-Debre-Fanconi syndrome were reported for the first time in 1977 [1]. In addition, recent studies reveal that focal glomerulosclerosis (FGS) and chronic renal failure are accompanied by mitochondrial abnormality [25]. Little is known, however, about the mechanism and progression of glomerular injury induced by mitochondrial mutations. We report a case of
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