Nephrol Dial Transplant (2002) 17: 11-14
© 2002 European Renal Association-European Dialysis and Transplant Association
Editorial Comments
-3 fatty acids in ESRD: should patients with ESRD eat more fish?
Saint Louis University School of Medicine, Division of Nephrology, St Louis, Missouri, USA
Keywords: fatty acids; fish oil; end-stage renal disease; blood pressure; vascular access
Introduction
-3 Fatty acids, derived from fish oil, are well established as essential nutrients in developing humans and adults [1]. However, their role as therapeutic agents in the management of progressive renal disease, atherosclerosis, and hypertension has only recently received attention [2]. For example, in patients with IgA nephropathy fish oil-enriched diets may retard progression of chronic renal insufficiency [3]. Moreover, these agents may confer specific benefits in end-stage renal disease (ESRD) including a reduction in blood pressure and vascular disease in light of recent data illuminating the cell biology of -3 fatty acids (see below).
Nomenclature of -3 fatty acids
Fatty acids with double bonds more distal than the sixth carbon from the (methyl) end of the parent hydrocarbon cannot be synthesized by humans and, therefore, must be ingested in the diet (Figure 1
). For example, linolenic acid, an essential fatty acid found in plant oil, possesses an
Cell biology of -3 fatty acids
Implications for ESRD
Vascular access thrombosis
Other complications of ESRD
Adverse effects
Future research
Acknowledgments
Notes
References
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