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Nephrol Dial Transplant (2001) 16: 1936-1938
© 2001 European Renal Association-European Dialysis and Transplant Association

Case Reports

Porphyria cutanea tarda precipitated by intravenous iron in a haemodialysis patient

William McKane1,, Christina A. Green2 and Ken Farrington1

Departments of 1Renal Medicine and 2 Dermatology, Lister Hospital, Coreys Mill Lane, Stevenage, Hertfordshire, UK

Keywords: porphyria; haemodialysis; intravenous iron; bullous dermatosis



   Introduction
 
Bullous dermatosis of haemodialysis (HD) was first documented by Gilchrest in 1975 [1], in a report describing five patients with cutaneous disease indistinguishable from porphyria cutanea tarda (PCT), but with no detectable abnormalities of porphyrin metabolism. It has since become clear that dialysis patients do have modestly elevated plasma porphyrin levels, with a pattern of accumulation that is similar, but not identical to that which occurs in PCT [2]. The term ‘pseudoporphyria’ has been used to describe dialysis patients with this PCT-like syndrome. This terminology is misleading, as pseudoporphyria is generally used to describe drug eruptions that mimic PCT, in patients with completely normal porphyrin metabolism. PCT is the commonest of the porphyrias, therefore it is not surprising that cases of true PCT have now been described in dialysis patients [3].

The relationship . . . [Full Text of this Article]



   Case
 


   Discussion
 


   Acknowledgments
 


   Notes
 


   References
 

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