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Nephrol Dial Transplant (2001) 16: 1475-1478
© 2001 European Renal Association-European Dialysis and Transplant Association

Case Report

Castleman's disease with nephrotic syndrome, amyloidosis and autoimmune manifestations

Simona Curioni1,2,, Marco D'Amico1,5, Rita Quartagno3, Stefania Martino1,3, Giacomo Dell'Antonio4 and Daniele Cusi1

1 Chair of Nephrology and Graduate School of Nephrology, University of Milan, 2 Division of Nephrology, S. Carlo Borromeo Hospital, 3 Division of Nephrology, Dialysis and Hypertension, S. Raffaele Hospital, 4 Department of Pathology, S. Raffaele Hospital, Milan, and 5 Division of Nephrology, A. Manzoni Hospital, Lecco, Italy

Keywords: AA amyloidosis; autoimmune manifestations; Castleman's disease (hyaline–vascular type); nephrotic syndrome; uveitis; venous thrombosis



   Introduction
 
Castleman's disease (also called giant lymph-node hyperplasia or angiofollicular lymph-node hyperplasia) is a highly heterogeneous clinico-pathological entity belonging to the lympho-proliferative disorders. Originally described in 1956 by Castleman and co-workers [1] as a large, benign, unique asymptomatic mass of mediastinal lymph nodes, it was shown in subsequent reports to include extra-mediastinal and multicentric forms [2].

Two histological patterns of lymph nodes were described: the hyaline–vascular and plasma-cell types. The former is more common (80–90%), and is characterized by the proliferation of capillary vessels in germinal centres of lymphatic folliculi, which assume a hyaline aspect. It is classically reported to have mono-localization, often mediastinal, and a benign course after removal of the mass. The plasma-cell variant is less frequent (10–20%) and presents hyperplastic follicles interspersed by sheets of plasma cells. It is often multi-centric and usually associated with systemic manifestations of inflammatory disease. The prognosis is worse, . . . [Full Text of this Article]



   Case
 


   Discussion
 


   Acknowledgments
 


   Notes
 


   References
 

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