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Nephrol Dial Transplant (2001) 16: 1309-1311
© 2001 European Renal Association-European Dialysis and Transplant Association

Editorial Comments

Vascular cytochrome P450 in the regulation of renal function and vascular tone: EDHF, superoxide anions and blood pressure

Ingrid Fleming and Rudi Busse

Institut für Kardiovaskuläre Physiologie, Klinikum der J.W.Goethe-Universität, Frankfurt am Main, Germany

Keywords: cytochrome P450; endothelium-derived hyperpolarizing factor; epoxyeicosatrienoic acids; nitric oxide; prostaglandins; renal function

Introduction

Renal cytochrome P450 (CYP)-dependent arachidonic acid metabolites have a wide and contrasting spectrum of biological effects. The profile and relative rates of eicosanoid production not only influence renal haemodynamics and tubular ion and water transport but may also play a determinant role in mechanisms associated with the development of hypertension. The eicosanoids generally thought to play major roles in regulating these functions are the epoxyeicosatrienoic acids (EETs) and their derivatives which activate Ca2+-dependent K+ (KCa) channels in endothelial and smooth-muscle cells, as well as 20-hydroxyeicosatetraenoic acid (20-HETE) which exerts an antagonistic effect on KCa channel activity. There are also reactive oxygen species (e.g. superoxide anions) generated during the enzymatic conversion of arachidonic acid by CYP within the vascular wall, which have both acute and chronic effects on vascular homeostasis.

NO, EDHF and the control of vascular tone

Nitric oxide . . . [Full Text of this Article]

Other actions of EETs

Other CYP-derived products

20-HETE and its interaction with NO

Soluble epoxide hydrolase and hypertension

Notes

References


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