Nephrol Dial Transplant (2001) 16: 843-845
© 2001 European Renal Association-European Dialysis and Transplant Association
Case Reports
Life-threatening thrombosis 18 years after first presentation of primary antiphospholipid antibody syndrome
1 Department of Renal Medicine and 2 Department of Radiology, Hammersmith Hospital, London
Keywords: antiphospholipid syndrome; aortic thrombosis; ß2 glycoprotein 1 antibodies; renal failure
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A 46-year-old woman presented at our renal unit for investigation of renal impairment. Of note in her past medical history, she had had several toes amputated while in her late twenties due to digital ischaemia. Investigations at that time had revealed a thrombotic stenosis of the left popliteal artery and occlusion of the anterior and posterior tibial vessels. She subsequently underwent successful arterial bypass grafting. Laboratory testing had revealed a positive anti-nuclear antibody (titre 1/160) but nothing else of note. There were no other clinical features to support a diagnosis of systemic lupus erythematosus (SLE). Empirical steroid therapy was given for a period and she was placed on long-term warfarin anticoagulation treatment.
Some 18 years later this woman
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