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Nephrol Dial Transplant (2001) 16: 840-842
© 2001 European Renal Association-European Dialysis and Transplant Association

Case Reports

Guillain–Barré syndrome as presenting feature in a patient with lupus nephritis, with complete resolution after cyclophosphamide treatment

Hanneke W. M. van Laarhoven1, Fergus A. Rooyer2,3, Baziel G. M. van Engelen2, Roelof van Dalen3 and Jo H. M. Berden,1

1Departments of Medicine, Division of Nephrology 2 Neurology 3 Intensive Care Medicine, University Medical Center Nijmegen, The Netherlands

Keywords: cyclophosphamide; Guillain–Barré syndrome; nephritis; systemic lupus erythematosus



   Introduction
 
Various neurological features have been reported in association with systemic lupus erythematosus (SLE). However, Guillain–Barré syndrome (GBS) as a presenting feature of SLE appears to be rare [1–3]. We report a patient presenting with GBS, in whom lupus nephritis was subsequently diagnosed. The GBS failed to respond to intravenous immunoglobulin treatment, but both GBS and lupus nephritis responded very favourably to intravenous pulses of cyclophosphamide and prednisone.



   Case
 
A 20-year-old woman was referred to our hospital because of a 10-day history of progressive muscle weakness of arms and legs, paraesthesias in both hands and feet, and diplopia. Her medical history was unremarkable. Physical examination on admission revealed a blood pressure of 150/110 mmHg and cardiac enlargement. Neurological examination showed a left abducens paresis, absent deep tendon reflexes, and . . . [Full Text of this Article]



   Discussion
 


   Acknowledgments
 


   Notes
 


   References
 

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