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Nephrol Dial Transplant (2001) 16: 615-618
© 2001 European Renal Association-European Dialysis and Transplant Association

Case Reports

Premature ageing and glomerulonephritis

Nicola Joss1,, J. Michael Boulton-Jones1 and Ian More2

1 Renal Unit, Glasgow Royal Infirmary, 2 Pathology Department, Western Infirmary, Glasgow, UK

Keywords: acquired cutis laxa; complement; mesangiocapillary glomerulonephritis; multiple myeloma; paraprotein



   Introduction
 
We present a case of a 37-year-old man with multiple myeloma, acquired cutis laxa, complement activation, and renal disease. The acquired form of cutis laxa may be associated with multiple myeloma, SLE, and coeliac disease [1–7]. Multiple myeloma can result in various types of renal disease, most commonly cast nephropathy, but also AL amyloid and light-chain-deposition disease, all of which have characteristic appearances on renal biopsy. Multiple myeloma is rarely associated with complement activation. As far as we know, this case, in which all conditions were present, is unique.



   Case
 
A 37-year-old man presented to our renal unit with a 6-month history of a changing skin appearance accompanied by a 2-month history of ankle swelling and shortness of breath. His only past medical history was . . . [Full Text of this Article]



   Discussion
 


   Notes
 


   References
 

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