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Nephrol Dial Transplant (2001) 16: 400-402
© 2001 European Renal Association-European Dialysis and Transplant Association

Case Reports

Reversible Fanconi syndrome after ingestion of a Chinese herbal ‘remedy’ containing aristolochic acid

Bernd Krumme, Roland Endmeir, Maurice Vanhaelen1 and Dieter Walb

Department of Nephrology, Deutsche Klinik für Diagnostik, Wiesbaden, Germany 1 Laboratory of Pharmacognosy and Bromatology, Institute de Pharmacie, Bruxelles, Belgium

Keywords: Chinese herbs nephropathy; Fanconi syndrome; interstitial nephropathy



   Introduction
 
Chinese herbs nephropathy (CHN) has been recognized as a separate entity of renal disease after ingestion of herbal medicine and had been primarily detected in Belgium [1]. It is characterized by a severe interstitial fibrosis, frequently progressing to end-stage renal failure (ESRF) [2]. In addition, tubular dysfunction as well as cellular abnormalities and cancer of the urothelium have been reported [3]. There is a striking histological similarity to the balkan endemic nephropathy, although the latter progresses much more slowly to ESRF [4].

Aristolochic acids, nephrotoxic and carcinogenic compounds have repeatedly been implicated in the pathogenesis of the syndrome [2]. They were recently identified in two patients in the UK who developed end-stage renal disease after ingesting Chinese herb remedies for the treatment of eczema [5].

We . . . [Full Text of this Article]



   Case
 


   Discussion
 


   Acknowledgments
 


   Notes
 


   References
 

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