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Nephrol Dial Transplant (2001) 16: 2258-2262
© 2001 European Renal Association-European Dialysis and Transplant Association

Case Reports

‘Full house’ positive immunohistochemical membranoproliferative glomerulonephritis in a patient with portosystemic shunt

Alexander De Smet1, Dirk Kuypers1,, Pieter Evenepoel1, Bart Maes1, Thierry Messiaen1, Boudewijn Van Damme2 and Yves Vanrenterghem1

1 Department of Nephrology, Renal Transplantation and 2 Department of Pathology, University Hospitals Leuven, Belgium

Keywords: full house immunostaining; liver cirrhosis; membranoproliferative glomerulonephritis; nephrotic syndrome; portosystemic shunt



   Introduction
 
The term membranoproliferative glomerulonephritis is used to describe a well defined histological form of glomerulonephritis characterized by mesangial proliferation and thickening of the capillary wall due to interposition of mesangial cells. If no triggering mechanism is identified, it is called primary membranoproliferative glomerulonephritis. Three main types can be differentiated; types I, II, and III. A different pathogenesis is suspected but not yet elucidated. Idiopathic or primary type I membranoproliferative glomerulonephritis with subendothelial electron dense deposits and hypocomplementaemia is usually associated with an immune complex-mediated pathogenesis [1]. A similar histological image can be seen with underlying viral, bacterial and parasitic infections, and autoimmune disorders such as systemic lupus erythematosus: secondary membranoproliferative glomerulonephritis. Reports of membranoproliferative glomerulonephritis in patients with a portosystemic shunt have also been described [2–4]. A functional bypass of the hepatic reticuloendothelial system by the portosystemic shunt and consequently reduced clearance of immune . . . [Full Text of this Article]



   Case
 


   Discussion
 


   Notes
 


   References
 

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N. Okamoto, S. Fukazawa, M. Shimamoto, R. Yamamoto, and Y. Fukazawa
Remission of membranoproliferative glomerulonephritis associated with a noncirrhotic portosystemic shunt after percutaneous transhepatic portal vein embolization
NDT Plus, June 1, 2009; 2(3): 228 - 232.
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