Nephrol Dial Transplant (2001) 16: 2253-2255
© 2001 European Renal Association-European Dialysis and Transplant Association
Case Reports
Membranous nephropathy from exposure to mercury in the fluorescent-tube-recycling industry
1 Medical Clinic I, Cologne City Hospital, Teaching Hospital University of Cologne and 2 Department of Pathology, University of Cologne, Germany
Keywords: membranous nephropathy; mercury exposure
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Mercury is a silvery white liquid metal that is volatile at room temperature due to its high vapour pressure. It exists in different oxidation states and can form a number of compounds. Mercury and its compounds can be absorbed into the human body by inhalation, ingestion, and through the skin. It is toxic when certain threshold values are exceeded. Acute toxicity is due to the inactivation of enzymes by the heavy metal, which leads to interstitial pneumonitis, ulcerative gastro-enteritis, or tubular necrosis, depending on the route of exposure. Long-term mercury poisoning affects mainly the central nervous system and the kidneys. In the latter case the nephrotoxicity is usually manifested as membranous glomerulonephritis (MGN) with nephrotic syndrome.
Since 1920, numerous cases of nephrotic syndrome due to long-term contact with mercury and mercury compounds have been reported. Mercurial diuretics (Mersalyl®), teething powders for young children, and mercury-containing ointments for psoriasis were
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