Nephrol Dial Transplant (2001) 16: 2232-2235
© 2001 European Renal Association-European Dialysis and Transplant Association
Brief Report
Past history of nephrolithiasis and incidence of hypertension in men: a reappraisal based on the results of the Olivetti Prospective Heart Study
1 Department of Clinical and Experimental Medicine, Unit of Clinical Genetics and Pharmacology, Hypertension and Mineral Metabolism and 3 Department of Preventive Medical Sciences, Federico II University Medical School, Naples, 2 Institute of Food Science and Technology, National Research Council, Avellino, Italy and 4 Department of General Practice and Primary Care, St George's Hospital Medical School, London, UK
Background. We have previously reported that in the Olivetti Prospective Heart Study cohort the incidence of nephrolithiasis was higher in hypertensive participants than in normotensive ones. As the time sequence and the mechanisms underlying the association between nephrolithiasis and hypertension remain controversial, we further tested the hypothesis that in a cohort of normotensive males a history of nephrolithiasis predicts the development of future hypertension.
Methods. The analysis was conducted in 381 male workers at Olivetti who were normotensive at the baseline examination and who were re-examined 8 years later.
Results. A past history of nephrolithiasis is associated with an increased risk of hypertension of 1.96 (95% CI=1.25–3.07) relative to subjects with a negative history, after adjusting for age.
Conclusion. In this 8-year follow-up study, a history of nephrolithiasis resulted in an increased risk of developing hypertension in the future. As the reverse was also true, as previously reported, a clear-cut time sequence, as well as the mechanisms linking these two conditions, remain to be identified.
Keywords: hypertension; nephrolithiasis; population study
Correspondence and offprint requests to: Pasquale Strazzullo, MD, Department of Clinical and Experimental Medicine, Federico II University of Naples Medical School, Via S. Pansini 5, I-80131 Napoli, Italy. Email: strazzul{at}unina.it
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