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Nephrol Dial Transplant (2000) 15: 69-71
© 2000 European Renal Association-European Dialysis and Transplant Association

Involvement of Angiotensin II in Tubulointerstitial Disease

ACE and {alpha}-adducin genotypes and renal disease progression

Carmine Zoccali

CNR Centro Fisiologia Clinica e Unità Operativa di Nefrologia, Dialisi e Trapianto Renale, Reggio Calabria, Italy

Abstract

In the REIN study of non-diabetic proteinuric nephropathies, renal disease progression was independent of the angiotensin-converting enzyme (ACE) and {alpha}-adducin genotypes. However, the ACE genotype predicted the renoprotective effect of ACE inhibition. Subgroup analysis in patients with Berger disease showed a tendency (NS) for a faster progression in DD homozygotes.


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